Her breakthrough role came in the 2001 high budget car-themed action film The Fast and the Furious, which was a worldwide success. Brewster began being widely recognized. Other film credites include the 2004 action comedy film D.E.B.S., the 2005 independent drama Nearing Grace and the 2006 horror film The Texas Chainsaw Massacre: The Beginning, for which she received two Teen Choice Award nominations.
She had a recurring role in the NBC television series Chuck and starred in the 2009 film Fast & Furious, the fourth installment of the The Fast and the Furious film series. After guest roles in several television shows such as Dark Blue and Gigantic, she appeared in the fifth film in the franchise, 2011's Fast Five, which gained critical praise, becoming the highest rated entry for Brewster. She will star in the television series Dallas.
Brewster co-starred in the fifth film of the The Fast and the Furious franchise, Fast Five. The film was released on April 29, 2011. The film told the story of Paul Walker and Vin Diesel's characters fighting against federal agents and a corrupt businessman. Filming of the movie began on June 28, 2010 in Rio de Janeiro and finished in October of that year. Fast Five opened to favorable reviews and has been a financial success, breaking box office records to become the highest grossing opening weekend in an April and the second highest opening weekend in Spring, earning $168 million.