Smith dropped out of high school and was married in 1985. Her highly publicized second marriage to oil business executive and mogul J. Howard Marshall, 62 years her senior, resulted in speculation that she married the octogenarian for his money, which she denied. Following Marshall's death, Smith began a lengthy legal battle over a share of his estate; her case, Marshall v. Marshall, reached the U.S. Supreme Court on a question of federal jurisdiction. She died on February 8, 2007 in a Hollywood, Florida hotel room as a result of an overdose of prescription drugs. Within the final six months of her life, Smith was the focus of renewed press coverage surrounding the death of her son, Daniel and the paternity and custody battle over her birth daughter Dannielynn.
The debut of The Anna Nicole Show was the highest rated series on the network, but critics blasted it and ratings dropped with each successive week. However, it achieved a cult status among some, particularly college fraternities. The show was canceled in February 2004 due to "creative differences," but has retained some life in reruns and on DVD releases.
Smith's next appearance on the big screen was as herself in Wasabi Tuna (2003), about a group of friends who kidnap her dog, Sugar-Pie, on Halloween. She appeared as herself again in Be Cool (2005), a crime/comedy about the film and music industries that stars John Travolta, Uma Thurman and The Rock. She produced and starred as "Lucy" in Illegal Aliens, a sci-fi/comedy about beautiful space aliens saving the earth from evil.