In 2003, Hayek produced and directed The Maldonado Miracle, a Showtime movie which won her a Daytime Emmy Award for Outstanding Directing in a Children/Youth/Family Special. In December 2005, she directed a music video for Prince, titled "Te Amo Corazon" ("I love you, sweetheart") that featured her good friend Mia Maestro.
Hayek at the 2008 Cannes Film Festival.
Hayek is an executive producer of Ugly Betty, a television series airing around the world since September 2006. Hayek adapted the series for American television with Ben Silverman, who acquired the rights and scripts from the Colombian telenovela Yo Soy Betty La Fea in 2001. Originally intended as a half hour sitcom for NBC in 2004, the project would later be picked up by ABC for the 2006–2007 season with Silvio Horta also producing. Hayek guest-starred on Ugly Betty as Sofia Reyes, a magazine editor. She also had a cameo playing an actress in the telenovela within the show. The show won a Golden Globe Award for Best Comedy Series in 2007. Hayek's performance as Sofia resulted in a nomination for Outstanding Guest Actress in a Comedy Series at the 59th Primetime Emmy Awards.
In April 2007, Hayek finalized negotiations with MGM to become the CEO of her own Latin themed film production company, Ventanarosa. The following month, she signed a two year deal with ABC to develop projects for the network through her production company, Ventanarosa.
Hayek is developing and producing La Banda, a Spanish-language romantic comedy set in Mexico, written by Issa Lopez.
Hayek recently had a guest stint on 30 Rock as Elisa, the nurse for Jack Donaghy's mother, for whom Jack falls.
Hayek stars as the wife of Adam Sandler in Grown Ups, which also co-stars Chris Rock and Kevin James. Salma is set to co-star with Antonio Banderas in the Shrek spin-off film Puss in Boots as the voice of the character Kitty, who serves as Puss' female counterpart and love interest.
