in March 2008 Olmstead stated that the character of Sara is still alive and would return in Season 4 of Prison Break. Though the character Sara Tancredi appeared to have a violent death Olmstead stated "...we realized that there was actually a way she could still be alive." When asked by Kirstin of E! whether the fans' overwhelming response to her death (namely the STGD Campaign and Save-Sara-Tancredi.org) had factored in, Executive Producer Matt Olmstead admitted it had indeed influenced the decision.
Callies has also starred in two feature films - Universal Pictures' Whisper and an independent film, The Celestine Prophecy.
In May 2010, she appeared on the Fox Television drama House MD as a patient of the week whose open marriage fascinates House and the team.
She portrays Lori Grimes in the upcoming horror/drama series The Walking Dead, based on the graphic novel series of the same name. Callies played one of the female lead roles in the upcoming Canadian thriller Faces in the Crowd. and she will also star in the drama film Four Saints as Mairi Chisholm.
In August 2010 Callies' first screenplay, an adaptation of Campbell Geeslin's children's book "Elena's Serenade", was optioned by producer Cameron Lamb and Canadian production company The Film Farm.
Callies is set to star in the movie "Black Gold", which will be released in 2011.