She has starred in two movie remakes (Taxi and Last Holiday), five sequels (House Party 2, Scary Movie 3, Barbershop 2: Back in Business, Ice Age: The Meltdown and Ice Age: Dawn of the Dinosaurs), one spinoff (Beauty Shop), two movies based on books (The Bone Collector and The Secret Life of Bees) and two screen adaptations of musicals (Chicago and Hairspray). The summer of 2007 brought Latifah triple success in the big-screen version of the Broadway smash hit Hairspray, in which she acted, sang, and danced. The film rated highly with critics. It starred, among others, John Travolta (Grease), Michelle Pfeiffer (Stardust), Allison Janney (Juno), James Marsden (Enchanted), Christopher Walken (Catch Me If You Can) and Zac Efron (High School Musical). Also in 2007, she portrayed an HIV-positive woman in the film Life Support, a role for which she garnered her first Golden Globe Award, Screen Actors Guild Award and an Emmy nomination. For her work, Queen Latifah received a star on the Hollywood Walk of Fame, on January 4, 2006, located at 6915 Hollywood Blvd.
Latifah produced the 2007 film The Perfect Holiday. In addition to producing the film, Latifah starred alongside Terrence Howard, Morris Chestnut, Gabrielle Union, Charles Q. Murphy, Jill Marie Jones, and Faizon Love. In 2008, Latifah appeared in the crime comedy Mad Money opposite Academy Award-winner Diane Keaton as well as Katie Holmes and Ted Danson. She appeared on Saturday Night Live on October 4, 2008, as moderator Gwen Ifill impersonator in a comedic sketch depicting the recent vice-presidential debate. In 2009, Latifah was a presenter at the 81st Academy Awards, presenting the segment honoring film professionals who had died during 2008 and singing "I'll Be Seeing You" during the montage. Latifah spoke at Michael Jackson's memorial service in Los Angeles. She also hosted the 2010 People's Choice Awards. Latifah sang America the Beautiful at Super Bowl XLIV hosted in Miami, Florida on February 7, 2010 with Carrie Underwood.May 18, 2010 BET announced that Latifah would be hosting the BET Awards on June 27, 2010 at 8 PM.